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Journal of Autism and Developmental Disorders

Gepubliceerd in:

08-05-2019 | Original Paper

A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder

Auteurs: Luke Bloy, Kobey Shwayder, Lisa Blaskey, Timothy P. L. Roberts, David Embick

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2019

Abstract

This study introduces an objective neurophysiological marker of language ability, the integral of event-related desynchronization in the 5–20 Hz band during 0.2–1 seconds post auditory stimulation with interleaved word/non-word tokens. This measure correlates with clinical assessment of language function in both ASD and neurotypical pediatric populations. The measure does not appear related to general cognitive ability nor autism symptom severity (beyond degree of language impairment). We suggest that this oscillatory brain activity indexes lexical search and thus increases with increased search in the mental lexicon. While specificity for language impairment in ASD remains to be determined, such an objective index has potential utility in low functioning individuals with ASD and young children during language acquisition.

vorige artikel Sustainability of a Care Pathway for Children and Adolescents with Autism Spectrum Disorder on an Inpatient Psychiatric Service

volgende artikel From Toddlerhood to Adolescence: Which Characteristics Among Toddlers with Autism Spectrum Disorder Predict Adolescent Attention Deficit/Hyperactivity Symptom Severity? A Long-Term Follow-Up Study

ERD

Event related desynchrony—task related decreases in oscillatory power relative to baseline

ERS

Event related synchrony—task related increases in oscillatory power relative to baseline

MEG

Magnetoencephalography

EEG

Electroencephalography

ASD

Autism spectrum disorder

Typically developing

M50/M100

Prominent middle and late components of the auditory evoked field

Lexical

Relating to the words or vocabulary

Theta Band

Oscillatory activity between 4 and 6 Hz

Alpha Band

Oscillatory activity between 8 and 12 Hz

Beta Band

Oscillatory activity between 13 and 30 Hz

Gamma Band

Oscillatory activity above 30 Hz (typically below 100 Hz)

STG

Superior temporal gyrus

ADOS-CSS

Calibrated severity score derived from the autism diagnostic observation schedule

PRI

Perceptual reasoning index from the wechsler intelligence scale for children-IV

CELF-CLSS

Core language standard score from the clinical evaluation of language fundamentals

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Titel: A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder
Auteurs: Luke Bloy
Kobey Shwayder
Lisa Blaskey
Timothy P. L. Roberts
David Embick
Publicatiedatum: 08-05-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04040-x

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A Spectrotemporal Correlate of Language Impairment in Autism Spectrum Disorder

Abstract

Andere artikelen Uitgave 8/2019

Perceived Barriers and Existing Challenges in Participation of Children with Autism Spectrum Disorders: “He Did Not Understand and No One Else Seemed to Understand Him”

Efficacy of Group-Based Organised Physical Activity Participation for Social Outcomes in Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis

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Perceived Barriers and Existing Challenges in Participation of Children with Autism Spectrum Disorders: “He Did Not Understand and No One Else Seemed to Understand Him”

Efficacy of Group-Based Organised Physical Activity Participation for Social Outcomes in Children with Autism Spectrum Disorder: A Systematic Review and Meta-analysis

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