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Gepubliceerd in:

01-03-2008 | Interuniversity Cardiology Institute of the Netherlands

Adrenergic regulation of conduction velocity in cultures of immature cardiomyocytes

Auteurs: T. P. de Boer, H. V. M. van Rijen, M. A. G. van der Heyden, J. M. T. de Bakker, T. A. B. van Veen

Gepubliceerd in: Netherlands Heart Journal | Uitgave 3/2008

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Abstract

During cardiac maturation, increased exposure of the heart to circulating catecholamines correlates with increased conduction velocity and growth of the heart. We used an in vitro approach to study the underlying mechanisms of adrenergic stimulation induced changes in conduction velocity. By combining functional measurements and molecular techniques, we were able to demonstrate that the increased conduction velocity after β-adrenergic stimulation is probably not caused by changes in intercellular coupling. Instead, RT-PCR experiments and action potential measurements have shown an increased excitability that may well explain the observed increase in conduction velocity. Apart from being relevant to cardiac maturation, our findings are relevant in the context of stem cells and cardiac repair. Preconditioning of stem cell derived cardiomyocytes may help to enhance electrical maturation of de novo generated cardiomyocytes and consequently reduce their proarrhythmogenic potential. (Neth Heart J 2008;16:106-9.)
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Metagegevens
Titel
Adrenergic regulation of conduction velocity in cultures of immature cardiomyocytes
Auteurs
T. P. de Boer
H. V. M. van Rijen
M. A. G. van der Heyden
J. M. T. de Bakker
T. A. B. van Veen
Publicatiedatum
01-03-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 3/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086127