This study included three waves of data, collected from approximately 890 African-American children and their families. Antecedents and consequences of psychiatric disorders among this population were examined. Children’s temperament, pubertal timing, and experience of stressful life events were tested as antecedents of psychiatric disorders. Several aspects of school functioning were then tested as consequences of psychiatric disorders. In addition, children with a single psychiatric disorder and those with comorbid disorders were statistically compared. Results showed that (1) children with at least one disorder, compared to those with no disorder, exhibited significantly more difficult temperament, experienced puberty earlier, and underwent greater numbers of stressful life events; (2) those with at least one disorder had significantly poorer school outcomes than those with no disorder; (3) children with comorbid disorders, compared with those who had only one disorder, displayed lower educational aspirations and poorer school commitment.