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Journal of Autism and Developmental Disorders
Gepubliceerd in:

01-09-2010 | Brief Report

Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder

Auteurs: Kenneth D. Gadow, Jasmin Roohi, Carla J. DeVincent, Sarah Kirsch, Eli Hatchwell

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2010

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Abstract

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
vorige artikel Digestive Enzyme Supplementation for Autism Spectrum Disorders: A Double-Blind Randomized Controlled Trial
volgende artikel Brief Report: Should the DSM V Drop Asperger Syndrome?
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Metagegevens
Titel
Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder
Auteurs
Kenneth D. Gadow
Jasmin Roohi
Carla J. DeVincent
Sarah Kirsch
Eli Hatchwell
Publicatiedatum
01-09-2010
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2010
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-0961-7

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