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Gepubliceerd in:

21-08-2018 | Brief Report

Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children

Auteurs: Eric Rubenstein, Jessica C. Young, Lisa A. Croen, Carolyn DiGuiseppi, Nicole F. Dowling, Li-Ching Lee, Laura Schieve, Lisa D. Wiggins, Julie Daniels

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2019

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Abstract

Opioid use during pregnancy is associated with suboptimal pregnancy outcomes. Little is known about child neurodevelopmental outcomes. We examined associations between maternal opioid prescriptions preconception to delivery (peri-pregnancy) and child’s risk of ASD, developmental delay/disorder (DD) with no ASD features, or ASD/DD with autism features in the Study to Explore Early Development, a case-control study of neurodevelopment. Preconception opioid prescription was associated with 2.43 times the odds of ASD [95% confidence interval (CI) 0.99, 6.02] and 2.64 times the odds of ASD/DD with autism features (95% CI 1.10, 6.31) compared to mothers without prescriptions. Odds for ASD and ASD/DD were non-significantly elevated for first trimester prescriptions. Work exploring mechanisms and timing between peri-pregnancy opioid use and child neurodevelopment is needed.
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Metagegevens
Titel
Brief Report: Maternal Opioid Prescription from Preconception Through Pregnancy and the Odds of Autism Spectrum Disorder and Autism Features in Children
Auteurs
Eric Rubenstein
Jessica C. Young
Lisa A. Croen
Carolyn DiGuiseppi
Nicole F. Dowling
Li-Ching Lee
Laura Schieve
Lisa D. Wiggins
Julie Daniels
Publicatiedatum
21-08-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3721-8