Positron emission tomography (PET) is the unrivalled imaging modality to quantitatively and noninvasively track biochemical pathways
in vivo. Perfusion is among those physiological processes that can accurately be evaluated.
1 More than any other technique, cardiac PET has greatly improved our understanding of human coronary vasomotor function in both physiological and pathophysiological conditions.
2 Furthermore, it has been demonstrated that the diagnostic accuracy of myocardial perfusion imaging (MPI) with PET for detecting obstructive coronary artery disease (CAD) surpasses that of single photon emission computed tomography (SPECT).
3,4 Nonetheless, owing to its limited availability and high costs, perfusion PET has predominantly been confined to the sideline in the clinical arena. …