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Psychological Research
Gepubliceerd in:

01-09-2014 | Original Article

Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency

Auteurs: Lorenza S. Colzato, Wery P. M. van den Wildenberg, Bernhard Hommel

Gepubliceerd in: Psychological Research | Uitgave 5/2014

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Abstract

The study investigated whether successful transfer of game-based cognitive improvements to untrained tasks might be modulated by preexisting neuro-developmental factors, such as genetic variability related to the catechol-O-methyltransferase (COMT)—an enzyme responsible for the degradation of dopamine. The COMT Val158Met genotype may differentially affect cognitive stability and flexibility, and we hypothesized that Val/Val homozygous individuals (who possess low prefrontal dopamine levels) show more pronounced cognitive flexibility than Met/-carriers (who possess high prefrontal dopamine levels). We trained participants, genotyped for the COMT Val158Met polymorphism on playing “Half-Life 2”, a first-person shooter game which has been shown to improve cognitive flexibility. Pre-training (baseline) and post-training measures of cognitive flexibility were acquired by means of a task-switching paradigm. As expected, Val/Val homozygous individuals showed larger beneficial transfer effects than Met/-carriers. Our findings support the idea that genetic predisposition modulates transfer effects and that playing first-person shooter games promotes cognitive flexibility in individuals with a suitable genetic predisposition.
vorige artikel Media multitasking and failures of attention in everyday life
volgende artikel A role for recency of response conflict in producing the bivalency effect
Literatuur
Bilder, R., Volavka, K., Lachman, H., & Grace, A. (2004). The Catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology, 29, 1943–1961.PubMedCrossRef
Boot, W. R., Kramer, A. F., Simons, D. J., Fabiani, M., & Gratton, G. (2008). The effects of video game playing on attention, memory, and executive control. Acta Psychologica, 129(3), 387–398.PubMedCrossRef
Brehmer, Y., Westerberg, H., Bellander, M., Fürth, D., Karlsson, S., & Bäckman, L. (2009). Working memory plasticity modulated by dopamine transporter genotype. Neuroscience Letters, 467(2), 117–120.PubMedCrossRef
Castel, A. D., Pratt, J., & Drummond, E. (2005). The effects of action video game experience on the time course of inhibition of return and the efficiency of visual search. Acta Psychologica, 119, 217–230.PubMedCrossRef
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., et al. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal Human Genetics, 75, 807–821.CrossRef
Clark, K., Fleck, M. S., & MitroV, S. R. (2011). Enhanced change detection performance reveals improved strategy use in avid action video game players. Acta Psychologica, 136, 67–72.PubMedCrossRef
Colzato, L. S., van den Wildenberg, W., Zmigrod, S., & Hommel, B. (2013). Action video gaming and cognitive control: playing first person shooter games is associated with improvement in working memory but not action inhibition. Psychological Research, 77(2), 234–239.PubMedCrossRef
Colzato, L. S., van Wouwe, N. C., Lavender, T., & Hommel, B. (2006). Intelligence and cognitive flexibility: fluid intelligence correlates with feature “unbinding” across perception and action. Psychonomic Bulletin and Review, 13, 1043–1048.PubMedCrossRef
Colzato, L. S., Waszak, F., Nieuwenhuis, S., Posthuma, D., & Hommel, B. (2010b). The flexible mind is associated with the Catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task switching. Neuropsychologia, 48, 2764–2768.PubMedCrossRef
Cools, R. (2006). Dopaminergic modulation of cognitive function: implication for L-DOPA therapy in Parkinson’s disease. Neuroscience and Biobehavioral Reviews, 30, 1–34.PubMedCrossRef
Cools, R., & D’Esposito, M. (2010). Dopaminergic modulation of flexible cognitive control in humans. In A. Björklund, S. Dunnett, L. Iversen, & S. Iversen (Eds.), Dopamine handbook (pp. 249–260). Oxford: Oxford University Press.
Crofts, H. S., Dalley, J. W., Van Denderen, J. C. M., Everitt, B. J., Robbins, T. W., & Roberts, A. C. (2001). Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set. Cerebral Cortex, 11, 1015–1026.PubMedCrossRef
DNA Genotek Inc. (2006). Oragene™ product brochure. Ottawa: DNA Genotek Inc.
Ettinger, U., Kumari, V., Collier, D. A., Powell, J., Luzi, S., Michel, T. M., Zedomi, O., & Williams, S. C. R. (2008). Catechol-O-Methyltransferase (COMT) Val158Met genotype is associated with BOLD response as a function of task characteristic. Neuropsychopharmacology, 33, 3046–3057.
Goschke, T. (2000). Involuntary persistence and intentional reconfiguration in task-set switching. In S. Monsell & J. Driver (Eds.), Attention and performance XVIII: control of cognitive processes (pp. 331–355). Cambridge: MIT Press.
Green, C. S., & Bavelier, D. (2003). Action video game modifies visual selective attention. Nature, 423, 534–537.PubMedCrossRef
Green, C. S., & Bavelier, D. (2006b). Effect of action video games on the spatial distribution of visuospatial attention. Journal of Experimental Psychology Human Perception and Performance, 32, 1465–1468.PubMedCentralPubMedCrossRef
Green, C. S., Sugarman, M. A., Medford, K., Klobusicky, E., & Bavelier, D. (2012). The effect of action video games on task switching. Computers in Human Behavior, 12, 984–994.CrossRef
Karle, J. W., Watter, S., & Shedden, J. M. (2010). Task switching in video game players: benefits of selective attention but not resistance to proactive interference. Acta Psychologica, 134(1), 70–78.PubMedCrossRef
Kray, J., Li, K. Z. H., & Lindenberger, U. (2002). Age-related changes in task-switching components: the role of task uncertainty. Brain and Cognition, 49, 363–381.PubMedCrossRef
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243–250.PubMedCrossRef
Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. (2000). The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cognitive Psychology, 41, 49–100.PubMedCrossRef
Monsell, S. (2003). Task switching. Trends in Cognitive Science, 7, 134–140.CrossRef
Nolan, K., Bilder, R., Lachman, H., & Volavka, K. (2004). Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. American Journal Psychiatry, 161, 359–361.CrossRef
Navon, D. (1977). Forest before trees: the precedence of global features in visual perception. Cognitive Psychology, 9, 353–383.
Owen, A. M., Hampshire, A., Grahn, J. A., Stenton, R., Dajani, S., Burns, A. S., et al. (2010). Putting brain training to the test. Nature, 465, 775–778.PubMedCentralPubMedCrossRef
Raven, J. C., Court, J. H., & Raven, J. (1988). Manual for Raven’s progressive matrices and vocabulary scales. London: Lewis.
Roberts, A. C., De Salvia, M. A., Wilkinson, L. S., Collins, P., Muir, J. L., Everitt, B. J., et al. (1994). 6-Hydroxydopamine lesions of the prefrontal cortex in monkeys enhance performance on an analog of the wisconsin card sort test: possible interactions with subcortical dopamine. Journal of Neuroscience, 14, 2531–2544.PubMed
Schott, B. H., Seidenbecher, C. I., Fenker, D. B., Lauer, C. J., Bunzeck, N., & Bernstein, H.-G. (2006). The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. Journal of Neuroscience, 26, 1407–1417.PubMedCrossRef
Strobach, T., Frensch, P. A., & Schubert, T. (2012). Video game practice optimizes executive control skills in dual-task and task switching situations. Acta Psychologica, 140(1), 13–24.PubMedCrossRef
Takeuchi, H., Sekiguchi, A., Taki, Y., Yokoyama, S., Yomogida, Y., Komuro, N., et al. (2010). Training of working memory impacts structural connectivity. Journal of Neuroscience, 30, 3297–3303.PubMedCrossRef
van Colzato, L. S., Muiden, J., Band, G., & Hommel, B. (2011). Genetic modulation of training and transfer in older adults: BDNF Val66Met polymorphism is associated with wider useful field of view. Frontiers in Cognition. doi:10.​3389/​fpsyg.​2011.​00199.
Metagegevens
Titel
Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency
Auteurs
Lorenza S. Colzato
Wery P. M. van den Wildenberg
Bernhard Hommel
Publicatiedatum
01-09-2014
Uitgeverij
Springer Berlin Heidelberg
Gepubliceerd in
Psychological Research / Uitgave 5/2014
Print ISSN: 0340-0727
Elektronisch ISSN: 1430-2772
DOI
https://doi.org/10.1007/s00426-013-0514-8

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