The main goal of this article is to propose a cognitive technology for blocking the impact of mental contamination during cognitive restructuring in cognitive-behavioral and rational-emotive therapy, by using fundamental research findings from cognitive psychology. In step 1, after a review of the relevant cognitive and social psychology literature, the authors elaborated several techniques hypothesized to control mental contamination. In step 2—Experiment I—the authors tested the efficacy of these techniques in blocking mental contamination. The three techniques that proved to be effective in controlling mental contamination were: (a) the global restructuring technique; (b) the rational anticipation technique; (c) the incompatible information technique. In step 3—Experiment II—these techniques were adapted and tested in clinical setting using a single case experiment design-multiple baselines across subjects (five subjects with simple phobia). The techniques were shown to be effective in both stimulating the assimilation of new adaptive cognitions (i.e., global restructuring and incompatible information technique) and in preventing relapse (i.e., rational anticipation technique). Future directions for research are discussed.