In this commentary, I argue that although emotion regulation and its role in psychopathology has been the focus of considerable psychological research with both children and adults, fundamental questions remain about how these phenomena are linked. I pose four challenges to the study of emotion regulation and psychopathology that have yet to be fully met, either empirically or conceptually. I note that a multi-level developmental approach that places emotion regulation within the context of both the larger self-regulatory system and the social relationships within which regulation occurs may be useful in understanding the emergence and maintenance of early behavioral patterns that evolve into disorders of psychological functioning.