The elbow, forearm, wrist and hand are the parts of the musculoskeletal system that are essential for functioning at a higher motor level. Injuries, both as a result of trauma and from chronic strain, are relatively common in this region and have a major impact on the quality of life. Recognition of the symptoms and knowledge of the natural course, form the basis for good treatment. Adjusting activities often already leads to recovery. In this chapter, an anatomical classification has been chosen, from elbow via forearm to wrist, hand and fingers, in which the most common conditions are discussed per location. The aim of this chapter is to provide adequate insight into these common disorders, their natural course and the effectiveness of the various treatment methods on the outcome and the patient’s ultimate functioning.