The current study examined the mediational effects of emotion dysregulation in terms of the relation between perceived distress tolerance and anxiety and depressive symptoms among HIV+ individuals. Participants included 176 HIV+ adults (21.6 % female, M
age = 48.40 years, SD = 8.66). Results indicated that distress tolerance was significantly related to greater depressive and anxiety symptoms. Results also indicated that emotion dysregulation mediated this association. The observed findings were evident above and beyond the variance accounted for by CD4 T-cell count, ethnicity, gender, education level, and cannabis use status. The results are discussed in terms of the potential explanatory utility of perceived distress tolerance and emotion dysregulation in terms of psychological well-being among HIV+ individuals.