As suicide continues to be a leading cause of death for Latino adolescents in the US, their caregivers are strategically positioned to be leaders in its prevention. This exploratory study examined Latino immigrant caregivers’ knowledge, engagement, and perceived self-efficacy about Latino adolescent suicide. Participants (N = 133) were first-generation Latino caregivers living in the United States. A multiple regression examined participants’ suicide literacy, suicide prevention reinforcement, family and cultural factors, and sociodemographic associations with suicide-related prevention communication self-efficacy (SPCS). Only 23% of participants were familiar with suicide prevention programming. Multiple regression results revealed that suicide prevention reinforcement, familism, and income were significantly associated with the Latino caregiver’s SPCS. The findings provide a baseline of Latino immigrant caregivers’ SPCS, which can be used to inform providers working with Latino families struggling with suicidality or who have a Latino adolescent at risk for suicide and inform the development of culturally-tailored suicide prevention programming.