There are over 30 different treatments for sensitive dentin on the market today which suggests that not one of them gives the immediate and lasting relief from this condition desired by the patient. In this chapter we describe several, emerging, novel experimental technologies that may, in the future, offer such relief. These technologies include: a synthetic “glue” resembling the adhesive that adheres mollusks to rocks in the ocean; a self-etch resin filled with fluorhydroxyapatite (FA) crystrals; and a flexible laminate of Eudragit filled with the FA srystals. Finally the incorporation of dendrimers (artificial proteins) functionalized with anti-inflammatories and anti-microbials to control inflammation beneath sensitive dentin and, overtime, help the pulp repair.