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Journal of Autism and Developmental Disorders

Gepubliceerd in:

29-05-2020 | Original Paper

Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults

Auteurs: Gizem Y. Yildiz, Julian S. Vilsten, Amy Siobhan Millard, Philippe A. Chouinard

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2021

Abstract

We examined whether functional and structural variability in the primary visual area (V1) correlated with autism traits. Twenty-nine participants (16 males; M_Age = 26.4 years, SD_Age = 4.0 years) completed the autism-spectrum quotient (AQ) questionnaire prior to a magnetic resonance imaging session. The total AQ scores was used to assess the degree of self-reported autism traits. The average functional activation in V1 to visual stimulation and its average grey-matter thickness were calculated. There were no correlations between functional activation in V1 and autism traits. Conversely, grey-matter thickness of the left but not the right V1 correlated with autism traits. We conclude that structural changes in the left V1 could be a marker for the presence of autism traits.

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American Psychiatric Association. (2013). DSM-V: Diagnostic and statistical manual of mental disorders, 5th edition. Washington: DC: American Psychiatric Publishing, Inc.

Amunts, K., Malikovic, A., Mohlberg, H., Schormann, T., & Zilles, K. (2000). Brodmann's areas 17 and 18 brought into stereotaxic space-where and how variable? Neuroimage, 11(1), 66–84. https://doi.org/10.1006/nimg.1999.0516.CrossRefPubMed

Ashwin, E., Ashwin, C., Rhydderch, D., Howells, J., & Baron-Cohen, S. (2009). Eagle-eyed visual acuity: An experimental investigation of enhanced perception in autism. Biological Psychiatry, 65(1), 17–21. https://doi.org/10.1016/j.biopsych.2008.06.012.CrossRefPubMed

Barnea-Goraly, N., Lotspeich, L. J., & Reiss, A. L. (2010). Similar white matter aberrations in children with autism and their unaffected siblings: A diffusion tensor imaging study using tract-based spatial statistics. Archives of General Psychiatry, 67(10), 1052–1060. https://doi.org/10.1001/archgenpsychiatry.2010.123.CrossRefPubMed

Baron-Cohen, S., Ring, H., Chitnis, X., Wheelwright, S., Gregory, L., Williams, S., et al. (2006). fMRI of parents of children with Asperger syndrome: A pilot study. Brain and Cognition, 61(1), 122–130. https://doi.org/10.1016/j.bandc.2005.12.011.CrossRefPubMed

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17. https://doi.org/10.1023/a:1005653411471.CrossRef

Baum, S. H., Stevenson, R. A., & Wallace, M. T. (2015). Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder. Progress in Neurobiology, 134, 140–160. https://doi.org/10.1016/j.pneurobio.2015.09.007.CrossRefPubMedPubMedCentral

Bertone, A., Mottron, L., Jelenic, P., & Faubert, J. (2005). Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity. Brain, 128(Pt 10), 2430–2441. https://doi.org/10.1093/brain/awh561.CrossRefPubMed

Bezgin, G., Lewis, J. D., & Evans, A. C. (2018). Developmental changes of cortical white-gray contrast as predictors of autism diagnosis and severity. Transl Psychiatry, 8(1), 249. https://doi.org/10.1038/s41398-018-0296-2.CrossRefPubMedPubMedCentral

Billeci, L., Calderoni, S., Conti, E., Gesi, C., Carmassi, C., Dell'Osso, L., et al. (2016). The broad autism (endo)phenotype: Neurostructural and neurofunctional correlates in parents of individuals with autism spectrum disorders. Frontiers in Neuroscience. https://doi.org/10.3389/fnins.2016.00346.CrossRefPubMedPubMedCentral

Bourgeron, T. (2015). From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nature Reviews Neuroscience, 16(9), 551–563. https://doi.org/10.1038/nrn3992.CrossRefPubMed

Brainard, D. H. (2011). The psychophysics toolbox. Spatial Vision, 10, 433–436.CrossRef

Cheung, C., Chua, S. E., Cheung, V., Khong, P. L., Tai, K. S., Wong, T. K. W., et al. (2009). White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism. Journal of Child Psychology and Psychiatry, 50(9), 1102–1112. https://doi.org/10.1111/j.1469-7610.2009.02086.x.CrossRefPubMed

Chouinard, P. A., Royals, K. A., Landry, O., & Sperandio, I. (2018). The Shepard illusion is reduced in children with an autism spectrum disorder because of perceptual rather than attentional mechanisms. Frontiers in Psychology, 9, 2452. https://doi.org/10.3389/fpsyg.2018.02452.CrossRefPubMedPubMedCentral

Chouinard, P. A., Unwin, K. L., Landry, O., & Sperandio, I. (2016). Susceptibility to optical illusions varies as a function of the autism-spectrum quotient but not in ways predicted by local-global biases. Journal of Autism and Developmental Disorders, 46(6), 2224–2239. https://doi.org/10.1007/s10803-016-2753-1.CrossRefPubMed

Dawson, G., Warrenburg, S., & Fuller, P. (1982). Cerebral lateralization in individuals diagnosed as autistic in early-childhood. Brain and Language, 15(2), 353–368. https://doi.org/10.1016/0093-934x(82)90065-7.CrossRefPubMed

Dumoulin, S. O., Hoge, R. D., Baker, C. L., Jr., Hess, R. F., Achtman, R. L., & Evans, A. C. (2003). Automatic volumetric segmentation of human visual retinotopic cortex. Neuroimage, 18(3), 576–587. https://doi.org/10.1016/s1053-8119(02)00058-7.CrossRefPubMed

Engel, S. A., Glover, G. H., & Wandell, B. A. (1997). Retinotopic organization in human visual cortex and the spatial precision of functional MRI. Cerebral Cortex, 7(2), 181–192. https://doi.org/10.1093/cercor/7.2.181.CrossRefPubMed

Gebauer, L., Foster, N. E. V., Vuust, P., & Hyde, K. L. (2015). Is there a bit of autism in all of us? Autism spectrum traits are related to cortical thickness differences in both autism and typical development. Research in Autism Spectrum Disorders, 13–14, 8–14. https://doi.org/10.1016/j.rasd.2014.12.013.CrossRef

Greimel, E., Schulte-Ruther, M., Kircher, T., Kamp-Becker, I., Remschmidt, H., Fink, G. R., et al. (2010). Neural mechanisms of empathy in adolescents with autism spectrum disorder and their fathers. Neuroimage, 49(1), 1055–1065. https://doi.org/10.1016/j.neuroimage.2009.07.057.CrossRefPubMed

Hadjikhani, N., Chabris, C. F., Joseph, R. M., Clark, J., McGrath, L., Aharon, I., et al. (2004). Early visual cortex organization in autism: An fMRI study. NeuroReport, 15(2), 267–270. https://doi.org/10.1097/01.wnr.0000107523.38715.fa.CrossRefPubMed

Hier, D. B., Lemay, M., & Rosenberger, P. B. (1979). Autism and unfavorable left-right asymmetries of the brain. Journal of Autism and Developmental Disorders, 9(2), 153–159. https://doi.org/10.1007/Bf01531531.CrossRefPubMed

Hyde, K. L., Samson, F., Evans, A. C., & Mottron, L. (2010). Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel-based morphometry. Human Brain Mapping, 31(4), 556–566. https://doi.org/10.1002/hbm.20887.CrossRefPubMed

Jeffreys, H. (1961). Theory of probability (3rd ed.). Oxford: Oxford University Press.

Keehn, B., Brenner, L., Palmer, E., Lincoln, A. J., & Muller, R. A. (2008). Functional brain organization for visual search in ASD. Journal of the International Neuropsychological Society, 14(6), 990–1003. https://doi.org/10.1017/S1355617708081356.CrossRefPubMed

Kemner, C., van Ewijk, L., van Engeland, H., & Hooge, I. (2008). Brief report: Eye movements during visual search tasks indicate enhanced stimulus discriminability in subjects with PDD. Journal of Autism and Developmental Disorders, 38(3), 553–557. https://doi.org/10.1007/s10803-007-0406-0.CrossRefPubMed

Kennedy, K. M., Rodrigue, K. M., Bischof, G. N., Hebrank, A. C., Reuter-Lorenz, P. A., & Park, D. C. (2015). Age trajectories of functional activation under conditions of low and high processing demands: An adult lifespan fMRI study of the aging brain. Neuroimage, 104, 21–34. https://doi.org/10.1016/j.neuroimage.2014.09.056.CrossRefPubMed

Koh, H. C., Milne, E., & Dobkins, K. (2010). Spatial contrast sensitivity in adolescents with autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(8), 978–987. https://doi.org/10.1007/s10803-010-0953-7.CrossRefPubMed

Lainhart, J. E. (2015). Brain imaging research in autism spectrum disorders: In search of neuropathology and health across the lifespan. Current Opinion in Psychiatry, 28(2), 76–82. https://doi.org/10.1097/Yco.0000000000000130.CrossRefPubMedPubMedCentral

Lainhart, J. E., & Lange, N. (2011). The biological broader autism phenotype. In G. D. D. G. Amaral & D. H. Geschwind (Eds.), Autism spectrum disorders. New York: Oxford University Press, Inc.

Landry, O., & Chouinard, P. A. (2016). Why we should study the broader autism phenotype in typically developing populations. Journal of Cognition and Development, 17(4), 584–595. https://doi.org/10.1080/15248372.2016.1200046.CrossRef

Loth, E., Garrido, L., Ahmad, J., Watson, E., Duff, A., & Duchaine, B. (2018). Facial expression recognition as a candidate marker for autism spectrum disorder: How frequent and severe are deficits? Molecular Autism. https://doi.org/10.1186/s13229-018-0187-7.CrossRefPubMedPubMedCentral

Macdonald, H., Rutter, M., Howlin, P., Rios, P., Leconteur, A., Evered, C., et al. (1989). Recognition and expression of emotional cues by autistic and normal adults. Journal of Child Psychology and Psychiatry and Allied Disciplines, 30(6), 865–877. https://doi.org/10.1111/j.1469-7610.1989.tb00288.x.CrossRef

Manjaly, Z. M., Bruning, N., Neufang, S., Stephan, K. E., Brieber, S., Marshall, J. C., et al. (2007). Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents. Neuroimage, 35(1), 283–291. https://doi.org/10.1016/j.neuroimage.2006.11.036.CrossRefPubMedPubMedCentral

Marco, E. J., Hinkley, L. B. N., Hill, S. S., & Nagarajan, S. S. (2011). Sensory processing in autism: A review of neurophysiologic findings. Pediatric Research, 69(5), 48r–54r. https://doi.org/10.1203/PDR.0b013e3182130c54.CrossRefPubMedPubMedCentral

O'Riordan, M. A. (2004). Superior visual search in adults with autism. Autism, 8(3), 229–248. https://doi.org/10.1177/1362361304045219.CrossRefPubMed

Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., et al. (1992). Intrinsic signal changes accompanying sensory stimulation—Functional brain mapping with magnetic-resonance-imaging. Proceedings of the National Academy of Sciences of the United States of America, 89(13), 5951–5955. https://doi.org/10.1073/pnas.89.13.5951.CrossRefPubMedPubMedCentral

Pelli, D. G. (1997). The VideoToolbox software for visual psychophysics: Transforming numbers into movies. Spatial Vision, 10, 437–442.CrossRef

Pellicano, E., & Burr, D. (2012). When the world becomes 'too real': A Bayesian explanation of autistic perception. Trends in Cognitive Sciences, 16(10), 504–510. https://doi.org/10.1016/j.tics.2012.08.009.CrossRefPubMed

Peterson, D., Mahajan, R., Crocetti, D., Mejia, A., & Mostofsky, S. (2015). Left-hemispheric microstructural abnormalities in children with high-functioning autism spectrum disorder. Autism Research, 8(1), 61–72. https://doi.org/10.1002/aur.1413.CrossRefPubMed

Peterson, E., Schmidt, G. L., Tregellas, J. R., Winterrowd, E., Kopelioff, L., Hepburn, S., et al. (2006). A voxel-based morphometry study of gray matter in parents of children with autism. NeuroReport, 17(12), 1289–1292. https://doi.org/10.1097/01.wnr.0000233087.15710.87.CrossRefPubMedPubMedCentral

Robertson, C. E., Thomas, C., Kravitz, D. J., Wallace, G. L., Baron-Cohen, S., Martin, A., et al. (2014). Global motion perception deficits in autism are reflected as early as primary visual cortex. Brain, 137(Pt 9), 2588–2599. https://doi.org/10.1093/brain/awu189.CrossRefPubMedPubMedCentral

Ruzich, E., Allison, C., Smith, P., Watson, P., Auyeung, B., Ring, H., et al. (2015). Measuring autistic traits in the general population: A systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females. Mol Autism, 6, 2. https://doi.org/10.1186/2040-2392-6-2.CrossRefPubMedPubMedCentral

Samson, F., Mottron, L., Soulieres, I., & Zeffiro, T. A. (2012). Enhanced visual functioning in autism: An ALE meta-analysis. Human Brain Mapping, 33(7), 1553–1581. https://doi.org/10.1002/hbm.21307.CrossRefPubMed

Sawyer-Glover, A. M., & Shellock, F. G. (2000). Pre-MRI procedure screening: Recommendations and safety considerations for biomedical implants and devices. Journal of Magnetic Resonance Imaging, 12(1), 92–106.CrossRef

Saxe, R., Brett, M., & Kanwisher, N. (2006). Divide and conquer: A defense of functional localizers. Neuroimage, 30(4), 1088–1096. https://doi.org/10.1016/j.neuroimage.2005.12.062.CrossRefPubMed

Schwarzkopf, D. S., Anderson, E. J., de Haas, B., White, S. J., & Rees, G. (2014). Larger extrastriate population receptive fields in autism spectrum disorders. Journal of Neuroscience, 34(7), 2713–2724. https://doi.org/10.1523/JNEUROSCI.4416-13.2014.CrossRefPubMed

Sereno, M. I., Dale, A. M., Reppas, J. B., Kwong, K. K., Belliveau, J. W., Brady, T. J., et al. (1995). Borders of multiple visual areas in humans revealed by functional magnetic-resonance-imaging. Science, 268(5212), 889–893. https://doi.org/10.1126/science.7754376.CrossRefPubMed

Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003). Mapping cortical change across the human life span. Nature Neuroscience, 6(3), 309–315. https://doi.org/10.1038/nn1008.CrossRefPubMed

Sperandio, I., Chouinard, P. A., & Goodale, M. A. (2012). Retinotopic activity in V1 reflects the perceived and not the retinal size of an afterimage. Nature Neuroscience, 15(4), 540–542. https://doi.org/10.1038/nn.3069.CrossRefPubMed

Sperandio, I., Unwin, K. L., Landry, O., & Chouinard, P. A. (2017). Size constancy is preserved but afterimages are prolonged in typical individuals with higher degrees of self-reported autistic traits. Journal of Autism and Developmental Disorders, 47(2), 447–459. https://doi.org/10.1007/s10803-016-2971-6.CrossRefPubMed

Tsermentseli, S., O'Brien, J. M., & Spencer, J. V. (2008). Comparison of form and motion coherence processing in autistic spectrum disorders and dyslexia. Journal of Autism and Developmental Disorders, 38(7), 1201–1210. https://doi.org/10.1007/s10803-007-0500-3.CrossRefPubMed

Vandenbroucke, M. W. G., Scholte, H. S., van Engeland, H., Lamme, V. A. F., & Kemner, C. (2008). A neural substrate for atypical low-level visual processing in autism spectrum disorder. Brain, 131, 1013–1024. https://doi.org/10.1093/brain/awm321.CrossRefPubMed

Wandell, B. A., & Winawer, J. (2011). Imaging retinotopic maps in the human brain. Vision Research, 51(7), 718–737. https://doi.org/10.1016/j.visres.2010.08.004.CrossRefPubMed

Yucel, G. H., Belger, A., Bizzell, J., Parlier, M., Adolphs, R., & Piven, J. (2015). Abnormal neural activation to faces in the parents of children with autism. Cerebral Cortex, 25(12), 4653–4666. https://doi.org/10.1093/cercor/bhu147.CrossRefPubMed

Titel: Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults
Auteurs: Gizem Y. Yildiz
Julian S. Vilsten
Amy Siobhan Millard
Philippe A. Chouinard
Publicatiedatum: 29-05-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04553-w

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Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults

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Andere artikelen Uitgave 2/2021

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