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Netherlands Heart Journal
Gepubliceerd in:

01-04-2009 | Interuniversity Cardiology Institute of the Netherlands

Late stent thrombosis, endothelialisation and drug-eluting stents

Auteurs: G. Ertaş, H. M. van Beusekom, W. J. van der Giessen

Gepubliceerd in: Netherlands Heart Journal | Uitgave 4/2009

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Abstract

Drug-eluting stents (DES) significantly reduce the risk of restenosis after percutaneous coronary revascularisation, but an increased risk of late stent thrombosis (LST) has been put forward as a major safety concern. Meta-analysis of clinical trials, however, does not support this caveat. Even so, many interventional cardiologists think that LST is associated with DES and related to delayed endothelialisation. This hypothesis is based on autopsy studies and clinical intracoronary angioscopy. In autopsy studies, differences between endothelialisation of DES and baremetal stents (BMS) have been reported. Most preclinical studies, however, have failed to show any significant differences in endothelialisation between DES and BMS. Our own studies, using the porcine coronary artery model, also suggest that DES show no differences in re-endothelialisation. However, DES do delay vascular healing and induce endothelial dysfunction. This paper will review clinical and animal studies which consider re-endothelialisation and LST. (Neth Heart J 2009;17:177–81.)
vorige artikel A 32-year-old woman with Down’s syndrome and central cyanosis
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Metagegevens
Titel
Late stent thrombosis, endothelialisation and drug-eluting stents
Auteurs
G. Ertaş
H. M. van Beusekom
W. J. van der Giessen
Publicatiedatum
01-04-2009
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 4/2009
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086242

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