This introductory paper briefly introduces the present special series, the purpose of which was to provide a forum for the systematic presentation of theory, empirical evidence, and directions for future work as it pertains to distress tolerance and psychopathology. Articles in the series were selected to highlight a broad range of research on topics dealing with distress tolerance and its relation to various aspects of psychopathology. The articles in this series collectively suggest the importance of developing more integrated models that explicitly integrate both basic and applied research in order to translate basic research on distress tolerance to the applied realm and cast such work in a more comprehensive nomological net.