We compared factors influencing adolescents’ self-control according to their family structure. Participants were 944 adolescents in five cities in South Korea (115 from single-parent families, 65 from grandparent-led families, and 764 from two-parent families). Data were collected using self-report questionnaires containing items on self-control, stress, parenting attitude, parent–adolescent communication, and family cohesion. Data were analyzed using stepwise multiple regressions with SPSS program. The factors influencing adolescents’ self-control differed across the three family structure groups. For single-parent families, stress and parental attitudes were significantly related to adolescents’ self-control (adjusted R2 = 0.37, p < 0.001). In contrast, for grandparent-led families, family cohesion and parental attitude were significantly related to adolescents’ self-control (adjusted R2 = 0.31, p < 0.01), while for two-parent families, stress, parental attitude, and parent–adolescent communication were related to the outcome (adjusted R2 = 0.24, p < 0.001). Parental attitude was thus a common factor relating to self-control, regardless of family structure. On the other hand, the main factors influencing adolescents with low self-control were gender and stress. Our results confirm that adolescents’ self-control is not only affected by personal factors but also by parental and family factors. It is important to improve individual program to improve adolescents’ self-control according to family structure. The results of study may act as a base for improving individual intervention programs aimed at promoting adolescents’ self-control by factoring in family structure.