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Quality of Life Research
Gepubliceerd in:

01-09-2012

Longitudinal changes in social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)

Auteurs: Francesco Patti, Maria Pia Amato, Maria Trojano, Stefano Bastianello, Maria Rosalia Tola, Orietta Picconi, Sabina Cilia, Salvatore Cottone, Luigi M. E. Grimaldi

Gepubliceerd in: Quality of Life Research | Uitgave 7/2012

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Abstract

Purpose

To report longitudinal changes in and explore the influence of cognition on social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis (RRMS).

Methods

Italian patients (18–50 years) with RRMS and Expanded Disability Status Scale (EDSS) score ≤4.0 were assigned to interferon β-1a, 44 or 22 μg subcutaneously three times weekly, and underwent annual assessments for social functioning (Environmental Status Scale [ESS]) over 3 years.

Results

Baseline total ESS score did not differ between patients with and without cognitive impairment (P = 0.505). Total ESS score remained low (<2.0) and stable over 3 years in the whole study population, but worsened slightly when assessed by assigned treatment or treatment and baseline cognitive status (both P = 0.004), driven mostly by changes in the ‘transportation’ and ‘financial/economic status’ subscales. The strongest independent predictor of worsening ESS score was baseline EDSS score. Test–retest analyses confirmed that total ESS score and most subscales changed little over 3 years.

Conclusion

ESS scores remained low and changed minimally over 3 years, reflecting the mild physical disability and good cognitive performance in this patient population. Determining the influence of cognitive function and treatment on longitudinal changes in social functioning requires further studies.
volgende artikel Measuring fatigue in persons with multiple sclerosis: creating a crosswalk between the Modified Fatigue Impact Scale and the PROMIS Fatigue Short Form
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Metagegevens
Titel
Longitudinal changes in social functioning in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)
Auteurs
Francesco Patti
Maria Pia Amato
Maria Trojano
Stefano Bastianello
Maria Rosalia Tola
Orietta Picconi
Sabina Cilia
Salvatore Cottone
Luigi M. E. Grimaldi
Publicatiedatum
01-09-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 7/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0021-6

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