Neurological disorders resulting from deregulation of the body’s internal milieu, problems with more peripheral organs, and the adverse effects of therapy are commonplace. It is important to identify the underlying ‘non-neurological’ substrate. This is essential for timely diagnosis and treatment, and to prevent additional or permanent neurological damage. This chapter is certainly not intended as study material, but rather as a reference work for neurological consultations in clinical departments or neurological outpatient clinics. As more and more therapies enter use, it is increasingly common to encounter neurological problems that are the adverse effects of therapy, or that result from an ongoing non-neurological disorder. This chapter considers the main topics.