This chapter focuses on the therapeutic approach to pain therapy in children with a pain disorder, as well as the organizational and structural premises of this approach. We present the evaluated inpatient pain therapy program of the German Paediatric Pain Centre, which is suited to children suffering from a monosymptomatic pain disorder, as well as those with a pain disorder coupled with mental or severe somatic comorbidities. Besides the program’s organization and structure, we present several case studies to elucidate specific aspects of our education program. We also present various clinically approved pain coping strategies and approaches. Finally, we present practical hints on how to integrate therapy into the family system, as well as procedures to follow in case of crisis, relapse, or any other unexpected difficulties.