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Quality of Life Research
Gepubliceerd in:

01-12-2012

The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis

Auteurs: Brian C. Healy, Irene R. Degano, Ana Schreck, David Rintell, Howard Weiner, Tanuja Chitnis, Bonnie I. Glanz

Gepubliceerd in: Quality of Life Research | Uitgave 10/2012

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Abstract

Purpose

In this study, we estimate the impact of a recent relapse on physical and mental health in subjects with relapsing-remitting multiple sclerosis (RRMS) using validated patient-reported outcome (PRO) measures.

Methods

Subjects enrolled in the Comprehensive Longitudinal Investigation of MS at the Brigham and Women’s Hospital with RRMS were eligible for enrollment. Subjects with a clinical visit within 45 days of a relapse were identified and divided into groups based on whether the relapse occurred before (recent relapse) (n = 59) or after the visit (pre-relapse) (n = 31). A group of subjects with no relapses was also identified (remission) (n = 336). PRO measures in these three groups were compared. All outcomes were compared using a t test and linear regression controlling for age, disease duration, sex, and EDSS.

Results

Subjects with a recent relapse had significantly worse functioning on several physical and mental health scales compared to subjects in remission even after adjusting for potential confounders. Subjects with a recent relapse also showed significant deterioration on PRO measures over 1 year compared to subjects in remission (P < 0.05 for each comparison). Subjects in the pre-relapse group were not significantly different than subjects in remission.

Conclusions

Clinical relapses have a measurable effect on PRO in subjects with RRMS.
volgende artikel The effect of weight loss on changes in health-related quality of life among overweight and obese women with urinary incontinence
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Metagegevens
Titel
The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis
Auteurs
Brian C. Healy
Irene R. Degano
Ana Schreck
David Rintell
Howard Weiner
Tanuja Chitnis
Bonnie I. Glanz
Publicatiedatum
01-12-2012
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 10/2012
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-011-0108-0

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