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Netherlands Heart Journal
Gepubliceerd in:

01-05-2013 | Original Article

The relationship between arterial wall stiffness and left ventricular dysfunction

Auteurs: Y. Hu, L. Li, L. Shen, H. Gao

Gepubliceerd in: Netherlands Heart Journal | Uitgave 5/2013

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Abstract

Objectives

The purpose of this study was to explore the relationship between left ventricular (LV) dysfunction and arterial wall stiffening.

Methods

A total of 218 patients over the age of 45 diagnosed with hypertension in Jinan City and hospitalised between 2010 and 2011 were included in this study. LV function was evaluated using echocardiography (ECHO). Blood pressure was monitored with an automated tonometric device, and the parameters of arterial wall stiffness were measured. In addition, the metabolic parameters of blood samples, such as glucose and lipids, were also determined using the Cobas E601 analyser.

Results

Stiffness parameter beta positively correlated with LV diastolic function (E/Em ratio) (r = 0.255, p < 0.001). LV end-diastolic diameter not only related to the E/Em ratio (r = 0.196, p = 0.009) but also with beta (r = 0.220, p = 0.002). The stiffness parameter beta was an early indicator of E/Em ratio as determined by multiple regression analysis (R 2 = 0.381, p < 0.01). Age, blood pressure and fasting blood glucose contributed to stiffness parameter beta (p < 0.05), as well as the E/Em ratio (p < 0.01).

Conclusions

Our findings suggested that LV dysfunction may have a direct relationship to arterial stiffening, independently of having similar risk factors. In addition, arterial stiffness can be an independent predictor of LV diastolic function, suggesting that the severity of arterial stiffness directly correlates with the severity of LV dysfunction.
vorige artikel Diastolic dysfunction and arterial stiffness: the chicken or the egg
volgende artikel Costs and benefits of treatment of myocardial infarction
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Metagegevens
Titel
The relationship between arterial wall stiffness and left ventricular dysfunction
Auteurs
Y. Hu
L. Li
L. Shen
H. Gao
Publicatiedatum
01-05-2013
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 5/2013
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/s12471-012-0353-z

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