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01-11-2009 | Study design article

Thrombus Aspiration during Percutaneous coronary intervention in Acute non-ST-elevation myocardial infarction Study (TAPAS II)-Study design

Auteurs: M. A. Kampinga, P. J. Vlaar, M. L. Fokkema, Y. L. Gu, F. Zijlstra

Gepubliceerd in: Netherlands Heart Journal | Uitgave 11/2009

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Extract

The pathogenesis of acute coronary syndromes (ACS) includes the rupture or erosion of a coronary atherosclerotic plaque with variable degrees of superimposed platelet aggregation inducing a thrombus.1,2 ST-elevation myocardial infarction (STEMI) is often caused by a total coronary occlusion of the atherothrombotic plaque, whereas in non-ST-elevation myocardial infarction (NSTEMI) the thrombus is mainly nonocclusive or transiently occlusive causing less myocardial damage.2 Conventional percutaneous coronary intervention (PCI) focuses on compressing the atherothrombotic plaque with the aim to normalise flow in the coronary artery and therefore restore perfusion of the ischaemic myocardium. However, embolisation of atherothrombotic material may occur spontaneously after plaque rupture or due to mechanical crushing of the culprit lesion during PCI.3,4 This results in obstruction of distal vessels or the microcirculation in the down-stream bed of the ischaemiarelated artery.4,5 Although normal epicardial flow may be achieved, this will lead to diminished myocardial perfusion, which is associated with larger infarct size, diminished left ventricular ejection fraction and increased mortality.6
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Metagegevens
Titel
Thrombus Aspiration during Percutaneous coronary intervention in Acute non-ST-elevation myocardial infarction Study (TAPAS II)-Study design
Auteurs
M. A. Kampinga
P. J. Vlaar
M. L. Fokkema
Y. L. Gu
F. Zijlstra
Publicatiedatum
01-11-2009
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 11/2009
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086293