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Journal of Autism and Developmental Disorders

Gepubliceerd in:

11-06-2021 | Original Paper

Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder

Auteurs: William E. DeCoteau, Adam E. Fox

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2022

Abstract

Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety.

vorige artikel Symptom Severity, Internalized and Externalized Behavioral and Emotional Problems: Links with Parenting Stress in Mothers of Children Recently Diagnosed with Autism

volgende artikel Challenges and Growth: Lived Experience of Adolescents and Young Adults (AYA) with a Sibling with ASD

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Titel: Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder
Auteurs: William E. DeCoteau
Adam E. Fox
Publicatiedatum: 11-06-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05129-y

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Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder

Abstract

Andere artikelen Uitgave 6/2022

A Deep Neural Network-Based Model for Screening Autism Spectrum Disorder Using the Quantitative Checklist for Autism in Toddlers (QCHAT)

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Welkom bij THIM Hogeschool voor Fysiotherapie & Bohn Stafleu van Loghum

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A Deep Neural Network-Based Model for Screening Autism Spectrum Disorder Using the Quantitative Checklist for Autism in Toddlers (QCHAT)

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