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Gepubliceerd in:

01-07-2008 | case report

Aborted sudden cardiac death in a 52-yearold man without structural heart disease

Auteurs: R. J. Walhout, R. J. de Winter, T. A. Simmers, E. M. Buijs

Gepubliceerd in: Netherlands Heart Journal | Uitgave 7/2008

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Extract

A 50-year-old man who had previously been in good general health was admitted to our department after an out-of-hospital cardiac arrest, with documented ventricular fibrillation. Normal sinus rhythm was restored by defibrillation and our patient experienced an uneventful neurological recovery. The baseline ECG was normal (figure 1). Apparent underlying heart disease, including myocardial ischaemia, was excluded by echocardiography, bicycle ergometry, coronary angiography and Holter monitoring. Flecainide drug challenge did not demonstrate Brugada ECG patterns. Electrophysiological study did not reveal any inducible ventricular arrhythmia. An implantable cardioverter defibrillator was inserted, which delivered therapy on two separate occasions during follow-up due to ventricular tachycardia. These events occurred two years after the index episode, six-months apart and on both occasions not related to exercise or other specific activity. Outpatient follow-up Holter monitoring demonstrated transient ST-segment elevation in the inferolateral ECG leads, during which the patient suffered from atypical chest discomfort in the early morning hours, not related to physical exertion (figure 2). Subsequently repeated coronary angiography, including fractional flow velocity reserve measurements, was normal. However, an extended and diffuse coronary spasm of the left descending coronary artery, occluding the first diagonal branch, was found following intracoronary administration of acetylcholine (figure 3). The spasm resolved and the flow was restored after administration of nitroglycerin. A calcium channel blocker, angiotensin-converting enzyme inhibitor, aspirin and statin therapy were started before discharge. Neither symptoms nor ICD therapy recurred during the following 18 months of follow-up.
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Metagegevens
Titel
Aborted sudden cardiac death in a 52-yearold man without structural heart disease
Auteurs
R. J. Walhout
R. J. de Winter
T. A. Simmers
E. M. Buijs
Publicatiedatum
01-07-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 7/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086153