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Gepubliceerd in:

01-05-2010 | Original article

Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium

Auteurs: W. T. Ruifrok, B. D. Westenbrink, R. A. de Boer, I. J. den Hamer, M. E. Erasmus, H. E. Mungroop, A. H. Epema, A. A. Voors, D. J. van Veldhuisen, W. H. van Gilst

Gepubliceerd in: Netherlands Heart Journal | Uitgave 5/2010

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Extract

Coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest is the most commonly used cardiac surgery procedure in the Western world.1 This procedure is associated with periods of oxygen deprivation and possibly a damaging effect to the Heart. Restoration of coronary blood flow after release of the aortic cross clamp leads to ischaemia-reperfusion injury. Subsequent production of reactive oxygen species results in cardiomyocyte death due to apoptosis.2-4 These changes may cause (transient) cardiac dysfunction,5,6 and therefore limiting the duration of cardioplegic arrest may reduce cell injury. …
Literatuur
1.
go back to reference Alexiou K, Kappert U, Staroske A, Joskowiak D, Wilbring M, Matschke K, et al. Coronary surgery for acute coronary syndrome: which determinants of outcome remain? Clin Res Cardiol. 2008;97:601-8. Alexiou K, Kappert U, Staroske A, Joskowiak D, Wilbring M, Matschke K, et al. Coronary surgery for acute coronary syndrome: which determinants of outcome remain? Clin Res Cardiol. 2008;97:601-8.
2.
go back to reference Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 2004;61:461-70. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 2004;61:461-70.
3.
go back to reference Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 2003;42:1075-81. Taniyama Y, Griendling KK. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension. 2003;42:1075-81.
4.
go back to reference Sugden PH, Clerk A. Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid Redox Signal. 2006;8:2111-24. Sugden PH, Clerk A. Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid Redox Signal. 2006;8:2111-24.
5.
go back to reference Sabbah HN, Sharov VG, Goldstein S. Cell death, tissue hypoxia and the progression of heart failure. Heart Fail Rev. 2000;5:131-8. Sabbah HN, Sharov VG, Goldstein S. Cell death, tissue hypoxia and the progression of heart failure. Heart Fail Rev. 2000;5:131-8.
6.
go back to reference Alexiou K, Kappert U, Staroske A, Joskowiak D, Wilbring M, Matschke K, et al. Coronary surgery for acute coronary syndrome: which determinants of outcome remain? Clin Res Cardiol. 2008;97:601-8. Alexiou K, Kappert U, Staroske A, Joskowiak D, Wilbring M, Matschke K, et al. Coronary surgery for acute coronary syndrome: which determinants of outcome remain? Clin Res Cardiol. 2008;97:601-8.
7.
go back to reference Morariu AM, Loef BG, Aarts LP, Rietman GW, Rakhorst G, van Oeveren W, et al. Dexamethasone: benefit and prejudice for patients undergoing on-pump coronary artery bypass grafting: a study on myocardial, pulmonary, renal, intestinal, and hepatic injury. Chest. 2005;128:2677-87. Morariu AM, Loef BG, Aarts LP, Rietman GW, Rakhorst G, van Oeveren W, et al. Dexamethasone: benefit and prejudice for patients undergoing on-pump coronary artery bypass grafting: a study on myocardial, pulmonary, renal, intestinal, and hepatic injury. Chest. 2005;128:2677-87.
8.
go back to reference de Boer RA, van Veldhuisen DJ, van der Wijk J, Brouwer RM, de Jonge N, Cole GM, et al. Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure. J Card Fail. 2000;6:330-7. de Boer RA, van Veldhuisen DJ, van der Wijk J, Brouwer RM, de Jonge N, Cole GM, et al. Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure. J Card Fail. 2000;6:330-7.
9.
go back to reference Beller CJ, Horvath E, Kosse J, Becker A, Radovits T, Krempien R, et al. Opposite effects of vascular irradiation on inflammatory response and apoptosis induction in the vessel wall layers via the peroxynitrite-poly(ADP-ribose) polymerase pathway. Clin Res Cardiol. 2007;96:8-16. Beller CJ, Horvath E, Kosse J, Becker A, Radovits T, Krempien R, et al. Opposite effects of vascular irradiation on inflammatory response and apoptosis induction in the vessel wall layers via the peroxynitrite-poly(ADP-ribose) polymerase pathway. Clin Res Cardiol. 2007;96:8-16.
10.
go back to reference Fischer UM, Tossios P, Huebner A, Geissler HJ, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2004;128:103-8. Fischer UM, Tossios P, Huebner A, Geissler HJ, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2004;128:103-8.
11.
go back to reference Tossios P, Bloch W, Huebner A, Raji MR, Dodos F, Klass O, et al. N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg. 2003;126:1513-20. Tossios P, Bloch W, Huebner A, Raji MR, Dodos F, Klass O, et al. N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: results of a randomized, double-blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg. 2003;126:1513-20.
12.
go back to reference Mehlhorn U, Krahwinkel A, Geissler HJ, LaRosee K, Fischer UM, Klass O, et al. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. J Thorac Cardiovasc Surg. 2003;125:178-83. Mehlhorn U, Krahwinkel A, Geissler HJ, LaRosee K, Fischer UM, Klass O, et al. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. J Thorac Cardiovasc Surg. 2003;125:178-83.
13.
go back to reference Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease--a novel therapeutic target? FASEB J.. 2002;16:135-46. Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease--a novel therapeutic target? FASEB J.. 2002;16:135-46.
14.
go back to reference Anselmi A, Abbate A, Girola F, Nasso G, Biondi-Zoccai GG, Possati G, et al. Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence. Eur J Cardiothorac Surg. 2004;25:304-11. Anselmi A, Abbate A, Girola F, Nasso G, Biondi-Zoccai GG, Possati G, et al. Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence. Eur J Cardiothorac Surg. 2004;25:304-11.
15.
go back to reference Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV. Two Large Preoperative Doses of Erythropoietin Do Not Reduce the Systemic Inflammatory Response to Cardiac Surgery. J Cardiothorac Vasc Anesth. 2008;23:316-23. Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV. Two Large Preoperative Doses of Erythropoietin Do Not Reduce the Systemic Inflammatory Response to Cardiac Surgery. J Cardiothorac Vasc Anesth. 2008;23:316-23.
16.
go back to reference Schmitt JP, Schroder J, Schunkert H, Birnbaum DE, Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg. 2002;73:1229-35. Schmitt JP, Schroder J, Schunkert H, Birnbaum DE, Aebert H. Role of apoptosis in myocardial stunning after open heart surgery. Ann Thorac Surg. 2002;73:1229-35.
17.
go back to reference Shalaby A, Rinne T, Jarvinen O, Saraste A, Laurikka J, Porkkala H, et al. Initial results of a clinical study: adenosine enhanced cardioprotection and its effect on cardiomyocytes apoptosis during coronary artery bypass grafting. Eur J Cardiothorac Surg. 2008;33:639-44. Shalaby A, Rinne T, Jarvinen O, Saraste A, Laurikka J, Porkkala H, et al. Initial results of a clinical study: adenosine enhanced cardioprotection and its effect on cardiomyocytes apoptosis during coronary artery bypass grafting. Eur J Cardiothorac Surg. 2008;33:639-44.
18.
go back to reference Flesch M, Knipp S, Kessler G, Geissler HJ, Massoudy P, Wilhelm H, et al. ARTA: AT1-receptor blocker therapy in patients undergoing coronary artery bypass grafting. Clin Res Cardiol. 2009;98:33-43. Flesch M, Knipp S, Kessler G, Geissler HJ, Massoudy P, Wilhelm H, et al. ARTA: AT1-receptor blocker therapy in patients undergoing coronary artery bypass grafting. Clin Res Cardiol. 2009;98:33-43.
19.
go back to reference Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci. 2005;6:484-94. Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci. 2005;6:484-94.
20.
go back to reference Chong ZZ, Kang JQ, Maiese K. Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab. 2002;22:503-14. Chong ZZ, Kang JQ, Maiese K. Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab. 2002;22:503-14.
21.
go back to reference Chong ZZ, Kang JQ, Maiese K. Angiogenesis and plasticity: role of erythropoietin in vascular systems. J Hematother Stem Cell Res. 2002;11:863-71. Chong ZZ, Kang JQ, Maiese K. Angiogenesis and plasticity: role of erythropoietin in vascular systems. J Hematother Stem Cell Res. 2002;11:863-71.
22.
go back to reference Lipsic E, Schoemaker RG, van der Meer P, Voors AA, van Veldhuisen DJ, van Gilst WH. Protective effects of erythropoietin in cardiac ischemia: from bench to bedside. J Am Coll Cardiol. 2006;48:2161-7. Lipsic E, Schoemaker RG, van der Meer P, Voors AA, van Veldhuisen DJ, van Gilst WH. Protective effects of erythropoietin in cardiac ischemia: from bench to bedside. J Am Coll Cardiol. 2006;48:2161-7.
23.
go back to reference Lipsic E, van der Meer P, Voors AA, Westenbrink BD, van den Heuvel AF, de Boer HC, et al. A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study. Cardiovasc Drugs Ther. 2006;20:135-41. Lipsic E, van der Meer P, Voors AA, Westenbrink BD, van den Heuvel AF, de Boer HC, et al. A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study. Cardiovasc Drugs Ther. 2006;20:135-41.
24.
go back to reference Haljan G, Maitland A, Buchan A, Arora RC, King M, Haigh J, et al. The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS). A Randomized, Double-Blind, Placebo Controlled, Proof-of-Concept Clinical Trial. Stroke. 2009, Epub ahead of print. Haljan G, Maitland A, Buchan A, Arora RC, King M, Haigh J, et al. The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS). A Randomized, Double-Blind, Placebo Controlled, Proof-of-Concept Clinical Trial. Stroke. 2009, Epub ahead of print.
25.
go back to reference Chong ZZ, Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation. 2002;106:2973-9. Chong ZZ, Kang JQ, Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation. 2002;106:2973-9.
26.
go back to reference Tramontano AF, Muniyappa R, Black AD, Blendea MC, Cohen I, Deng L, et al. Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun. 2003;308:990-4. Tramontano AF, Muniyappa R, Black AD, Blendea MC, Cohen I, Deng L, et al. Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun. 2003;308:990-4.
27.
go back to reference Hanlon PR, Fu P, Wright GL, Steenbergen C, Arcasoy MO, Murphy E. Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J. 2005;19:1323-5. Hanlon PR, Fu P, Wright GL, Steenbergen C, Arcasoy MO, Murphy E. Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J. 2005;19:1323-5.
28.
go back to reference Bullard AJ, Govewalla P, Yellon DM. Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo. Basic Res Cardiol. 2005;100:397-403. Bullard AJ, Govewalla P, Yellon DM. Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo. Basic Res Cardiol. 2005;100:397-403.
Metagegevens
Titel
Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium
Auteurs
W. T. Ruifrok
B. D. Westenbrink
R. A. de Boer
I. J. den Hamer
M. E. Erasmus
H. E. Mungroop
A. H. Epema
A. A. Voors
D. J. van Veldhuisen
W. H. van Gilst
Publicatiedatum
01-05-2010
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 5/2010
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03091769