The current article provides an overview of the papers included in this special issue on the cognitive and self-regulation aspects of perfectionism and their implications for treatment. Themes expressed in these papers include the association between perfectionism and deficits in cognitive self-management, the significant link between distress and automatic thoughts reflecting the need to be perfect, the importance of examining mediators and moderators of the association between perfectionism and psychological distress, and the specific role of perfectionism in suicidal tendencies and self-harm. It is also argued that certain core features of perfectionism and its associated correlates tend to impede treatment progress. Central factors associated with perfectionism that have a deleterious impact on treatment progress include the fear of failure and fear of embarrassment and exposure, a punishing orientation toward the self, pessimism and hopelessness about the possibility of recovery, and a rigid adherence to unrealistic goals and standards, including goals for treatment and recovery. We describe case studies illustrating treatment resistance among perfectionists and we reiterate the growing need for empirical research on the efficacy of clinical interventions designed for perfectionists.