The current study examined variables (daily hassles, self-esteem, dispositional optimism, coping modes, and perceived social support) that could potentially moderate associations between dimensions of perfectionism and current feelings of hopelessness and suicide ideation in university students (144 women; 61 men). Our study revealed several significant findings: (1) socially prescribed perfectionism was a significant predictor of suicide ideation, interpersonal hopelessness, and achievement hopelessness for both women and men; (2) self-oriented perfectionism did not have an independent relation with any of the suicide risk outcome variables in either women or men; (3) other-oriented perfectionism was associated negatively with both current hopelessness, particularly interpersonal hopelessness, and suicide ideation in men; (4) the cluster of proposed moderators accounted for additional unique variance in all suicide risk variables in women but in achievement hopelessness only in men; (5) optimism and social hassles were unique predictors but the results varied as a function of gender and outcome; (6) each perfectionism component interacted with specific moderators to enhance or buffer the link between perfectionism and suicide risk. The findings indicate that self-oriented and other-oriented perfectionism are possibly adaptive or maladaptive under certain conditions. Implications for the development of comprehensive, multidimensional, integrated models of the perfectionism–suicide risk link and for prevention and treatment in perfectionists at risk of suicide are discussed.