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Journal of Autism and Developmental Disorders

Gepubliceerd in:

17-05-2019 | Original Paper

Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?

Auteurs: Daniel Berends, Cheryl Dissanayake, Lauren P. Lawson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2019

Abstract

Previous research has found multiplex (MPX) children have an advantage in cognition compared to simplex (SPX) children. However, MPX parent’s previous experience with older diagnosed siblings has not been considered. We used a large database sample to investigate the MPX advantage and contribution of birth order. Children from the Autism Genetic Resource Exchange (AGRE) were stratified into first- (MPX¹, n = 152) and second-affected MPX (MPX², n = 143), SPX (n = 111), and only-child SPX (SPX^OC, n = 23) groups. Both MPX groups had higher cognitive scores compared to SPX groups, with no differences between MPX¹ and MPX² groups. No differences were found for autism symptoms or adaptive behaviour. These results suggest parent experience due to birth order is an unlikely contributor to the MPX cognitive advantage.

vorige artikel A Systematic Review of What Barriers and Facilitators Prevent and Enable Physical Healthcare Services Access for Autistic Adults

volgende artikel An In-Depth Analysis of Expository Writing in Children With and Without Autism Spectrum Disorder

Amiet, C., Gourfinkel-An, I., Laurent, C., Carayol, J., Génin, B., Leguern, E., et al. (2013). Epilepsy in simplex Autism pedigrees is much lower than the rate in multiplex Autism pedigrees. Biological Psychiatry, 74, e3–e4. https://doi.org/10.1016/j.biopsych.2013.01.037.CrossRefPubMed

Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T. R., et al. (2010). A genome-wide scan for common alleles affecting risk for autism. Human Molecular Genetics, 19(20), 4072–4082. https://doi.org/10.1093/hmg/ddq307.CrossRefPubMedPubMedCentral

Autism Genetic Resource Exchange. (2017). Diagnostic Information. http://research.agre.org/program/diag.cfm.

Banach, R., Thompson, A., Szatmari, P., Goldberg, J., Tuff, L., Zwaigenbaum, L., et al. (2008). Brief Report: Relationship between non-verbal IQ and gender in autism. Journal of Autism and Developmental Disorders, 39(1), 188. https://doi.org/10.1007/s10803-008-0612-4.CrossRefPubMed

Bourgeron, T. (2016). Current knowledge on the genetics of autism and propositions for future research. Comptes Rendus Biologies, 339(7), 300–307. https://doi.org/10.1016/j.crvi.2016.05.004.CrossRefPubMed

Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., et al. (2006). A genetic variant that disrupts MET transcription is associated with autism. Proceedings of the National Academy of Sciences of the United States, 103(45), 16834. https://doi.org/10.1073/pnas.0605296103.CrossRef

Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of Autism Spectrum Disorder among children Aged 8 Years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2012. MMWR Surveillance Summaries, 65(3), 1–23. https://doi.org/10.15585/mmwr.ss6503a1.CrossRefPubMedCentral

Clark, M. L. E., Vinen, Z., Barbaro, J., & Dissanayake, C. (2018). School age outcomes of children diagnosed early and later with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 48(1), 92–102. https://doi.org/10.1007/s10803-017-3279-x.CrossRefPubMed

Cuccaro, M. L., Shao, Y., Bass, M. P., Abramson, R. K., Ravan, S. A., Wright, H. H., et al. (2003). Behavioral comparisons in Autistic individuals from multiplex and singleton families. Journal of Autism and Developmental Disorders, 33(1), 87–91. https://doi.org/10.1023/a:1022286622534.CrossRefPubMed

Davis, J. M., Keeney, J. G., Sikela, J. M., & Hepburn, S. (2013). Mode of genetic inheritance modifies the association of head circumference and autism-related symptoms: A cross-sectional study (research article). PLoS ONE, 8(9), e74940. https://doi.org/10.1371/journal.pone.0074940.CrossRefPubMedPubMedCentral

Davis-Kean, P. E. (2005). The influence of parent education and family income on child achievement: The indirect role of parental expectations and the home environment. Journal of Family Psychology, 19(2), 294–304. https://doi.org/10.1037/0893-3200.19.2.294.CrossRefPubMed

De la Marche, W., Noens, I., Kuppens, S., Spilt, J., Boets, B., & Steyaert, J. (2015). Measuring quantitative autism traits in families: Informant effect or intergenerational transmission? European Child and Adolescent Psychiatry, 24(4), 385–395. https://doi.org/10.1007/s00787-014-0586-z.CrossRefPubMed

Dissanayake, C., Searles, J., Barbaro, J., Sadka, N., & Lawson, L. (2019). Cognitive and behavioural differences in toddlers with autism spectrum disorder from multiplex and simplex families. Autism Research. https://doi.org/10.1002/aur.2074.CrossRefPubMed

Donaldson, C. K., Stauder, J. E. A., & Donkers, F. C. L. (2017). Increased sensory processing atypicalities in parents of multiplex ASD families versus typically developing and simplex ASD families. Journal of Autism and Developmental Disorders, 47(3), 535–548. https://doi.org/10.1007/s10803-016-2888-0.CrossRefPubMed

Folstein, S. E., & Rosen-Sheidley, B. (2001). Genetics of autism: Complex aetiology for a heterogeneous disorder. Nature Reviews Genetics, 2(12), 943.CrossRefPubMed

Gerdts, J., Bernier, R., Dawson, G., & Estes, A. (2013). The broader autism phenotype in simplex and multiplex families. Journal of Autism and Developmental Disorders, 43(7), 1597–1605. https://doi.org/10.1007/s10803-012-1706-6.CrossRefPubMed

Hackman, D. A., Martha, J. F., & Michael, J. M. (2010). Socioeconomic status and the brain: Mechanistic insights from human and animal research. Nature Reviews Neuroscience, 11(9), 651. https://doi.org/10.1038/nrn2897.CrossRefPubMedPubMedCentral

Herlihy, L., Knoch, K., Vibert, B., & Fein, D. (2015). Parents first concerns about toddlers with Autism Spectrum Disorder: Effect of sibling status. Autism: The International Journal of Research and Practice, 19(1), 20–28. https://doi.org/10.1177/1362361313509731.CrossRef

Hoekstra, R. A., & Wheelwright, S. (2010). Autistic traits in simplex and multiplex autism families: Focus on unaffected relatives. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 153(1), 356–358. https://doi.org/10.1002/ajmg.b.30947.CrossRef

Hu, V. W., Sarachana, T., Kim, K. S., Nguyen, A., Kulkarni, S., Steinberg, M. E., et al. (2009). Gene expression profiling differentiates autism case–controls and phenotypic variants of autism spectrum disorders: Evidence for circadian rhythm dysfunction in severe autism. Autism Research, 2(2), 78–97. https://doi.org/10.1002/aur.73.CrossRefPubMedPubMedCentral

Hu, V. W., & Steinberg, M. E. (2009). Novel clustering of items from the autism diagnostic interview-revised to define phenotypes within autism spectrum disorders. Autism Research, 2(2), 67–77. https://doi.org/10.1002/aur.72.CrossRefPubMedPubMedCentral

Hus, V., Gotham, K., & Lord, C. (2014). Standardizing ADOS domain scores: Separating severity of social affect and restricted and repetitive behaviors. Journal of Autism and Developmental Disorders, 44(10), 2400–2412. https://doi.org/10.1007/s10803-012-1719-1.CrossRefPubMedPubMedCentral

Kosmicki, J. A., Samocha, K. E., Howrigan, D. P., Sanders, S. J., Slowikowski, K., Lek, M., et al. (2017). Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples. Nature Genetics. https://doi.org/10.1038/ng.3789.CrossRefPubMedPubMedCentral

Lord, C. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles: Western Psychological Services.

Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. https://doi.org/10.1023/a:1005592401947.CrossRefPubMed

Lord, C., Rutter, M., & Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685. https://doi.org/10.1007/bf02172145.CrossRefPubMed

Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule: ADOS manual. Los Angeles: Western Psychological Services.

Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 147B(4), 424–433. https://doi.org/10.1002/ajmg.b.30612.CrossRef

Mercati, O., & Chaste, P. (2015). From autism to autism spectrum disorders. Autism Spectrum Disorders, 180, 1–4. https://doi.org/10.1159/000366575.CrossRef

Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.

O’Roak, B. J., Stessman, H. A., Boyle, E. A., Witherspoon, K. T., Martin, B., Lee, C., et al. (2014). Recurrent de novo mutations implicate novel genes underlying simplex autism risk. Nature Communications. https://doi.org/10.1038/ncomms6595.CrossRefPubMed

Oerlemans, A. M., Hartman, C. A., Franke, B., Buitelaar, J. K., & Rommelse, N. N. J. (2016). Does the cognitive architecture of simplex and multiplex ASD families differ? Journal of Autism and Developmental Disorders, 46(2), 489–501. https://doi.org/10.1007/s10803-015-2572-9.CrossRefPubMed

Orsmond, G. I., Lin, L.-Y., & Seltzer, M. M. (2007). Mothers of adolescents and adults with autism: Parenting multiple children with disabilities. Intellectual and Developmental Disabilities, 45(4), 257–270. https://doi.org/10.1352/1934-9556(2007)45%5b257:moaaaw%5d2.0.co;2.CrossRefPubMed

Pandey, J. (2008). The Modified Checklist for Autism in Toddlers (M-CHAT) sibling study: Are younger siblings representative of the general ASD population?. Storrs, CT: University of Connecticut.

Perry, A., Flanagan, H. E., Dunn Geier, J., & Freeman, N. L. (2009). Brief Report: The Vineland Adaptive Behavior Scales in young children with Autism Spectrum Disorders at different cognitive levels. Journal of Autism and Developmental Disorders, 39(7), 1066–1078. https://doi.org/10.1007/s10803-009-0704-9.CrossRefPubMed

Piven, J., Tsai, G., Nehme, E., Coyle, J., Chase, G., & Folstein, S. (1991). Platelet serotonin, a possible marker for familial autism. Journal of Autism and Developmental Disorders, 21(1), 51–59. https://doi.org/10.1007/bf02206997.CrossRefPubMed

Puleo, C. M., Schmeidler, J., Reichenberg, A., Kolevzon, A., Soorya, L. V., Buxbaum, J. D., et al. (2012). Advancing paternal age and simplex autism. Autism, 16(4), 367–380. https://doi.org/10.1177/1362361311427154.CrossRefPubMed

Robinson, E., Samocha, K., Kosmicki, J., McGrath, L., Neale, B. M., Perlis, R. H., et al. (2014). Autism spectrum disorder severity reflects the average contribution of de novo and familial influences. Proceedings of the National Academy of Sciences of USA, 111(42), 15161–15165. https://doi.org/10.1073/pnas.1409204111.CrossRef

Rohrer, J. M., Egloff, B., & Schmukle, S. C. (2015). Examining the effects of birth order on personality. Proceedings of the National Academy of Sciences of USA, 112(46), 14224. https://doi.org/10.1073/pnas.1506451112.CrossRef

Roid, G. H. (2003). Stanford–Binet intelligence scales, fifth edition: Technical manual. Itasca, IL: Riverside Publishing.

Sacrey, L. A. R., Zwaigenbaum, L., Szatmari, P., Bryson, S., Georgiades, S., Brian, J., et al. (2017). Brief Report: Characteristics of preschool children with ASD vary by ascertainment. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-017-3062-z.CrossRefPubMed

Schatz, J., & Hamdan-Allen, G. (1995). Effects of age and IQ on adaptive behavior domains for children with autism. Journal of Autism and Developmental Disorders, 25(1), 51–60. https://doi.org/10.1007/bf02178167.CrossRefPubMed

Schwichtenberg, A. J., Young, G. S., Sigman, M., Hutman, T., & Ozonoff, S. (2010). Can family affectedness inform infant sibling outcomes of Autism Spectrum Disorders? Journal of Child Psychology and Psychiatry, 51(9), 1021–1030. https://doi.org/10.1111/j.1469-7610.2010.02267.x.CrossRefPubMed

Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., et al. (2007). Strong association of de novo copy number mutations with autism. Science, 316(5823), 445–449. https://doi.org/10.1126/science.1138659.CrossRefPubMedPubMedCentral

Sparrow, S. S., Balla, D. A., & Cicchetti, D. (1984). Vineland adaptive behaviour scales. Circle Pines, MN: American Guidance Service.

Taylor, L. J., Maybery, M. T., Wray, J., Ravine, D., Hunt, A., & Whitehouse, A. J. O. (2015). Are there differences in the behavioural phenotypes of Autism Spectrum Disorder probands from simplex and multiplex families? Research in Autism Spectrum Disorders, 11, 56–62. https://doi.org/10.1016/j.rasd.2014.12.003.CrossRef

Veatch, O. J., Veenstra-VanderWeele, J., Potter, M., Pericak-Vance, M. A., & Haines, J. L. (2014). Genetically meaningful phenotypic subgroups in autism spectrum disorders. Genes, Brain and Behavior, 13(3), 276–285. https://doi.org/10.1111/gbb.12117.CrossRef

Virkud, Y. V., Todd, R. D., Abbacchi, A. M., Zhang, Y., & Constantino, J. N. (2009). Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics, 150B(3), 328. https://doi.org/10.1002/ajmg.b.30810.CrossRef

Weiner, D. J., Wigdor, E. M., Ripke, S., Walters, R. K., Kosmicki, J. A., Grove, J., et al. (2017). Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders (Analysis). Nature Genetics, 49(7), 978–985. https://doi.org/10.1038/ng.3863.CrossRefPubMedPubMedCentral

Zwaigenbaum, L., Thurm, A., Stone, W., Baranek, G., Bryson, S., Iverson, J., et al. (2007). Studying the emergence of Autism Spectrum Disorders in high-risk infants: Methodological and practical issues. Journal of Autism and Developmental Disorders, 37(3), 466–480. https://doi.org/10.1007/s10803-006-0179-x.CrossRefPubMed

Titel: Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?
Auteurs: Daniel Berends
Cheryl Dissanayake
Lauren P. Lawson
Publicatiedatum: 17-05-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04052-7

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Differences in Cognition and Behaviour in Multiplex and Simplex Autism: Does Prior Experience Raising a Child with Autism Matter?

Abstract

Andere artikelen Uitgave 8/2019

Teaching Digital, Block-Based Coding of Robots to High School Students with Autism Spectrum Disorder and Challenging Behavior

Sustainability of a Care Pathway for Children and Adolescents with Autism Spectrum Disorder on an Inpatient Psychiatric Service

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Welkom bij THIM Hogeschool voor Fysiotherapie & Bohn Stafleu van Loghum

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Sustainability of a Care Pathway for Children and Adolescents with Autism Spectrum Disorder on an Inpatient Psychiatric Service

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