Non-informative, task-irrelevant auditory alerting signals often lead to increased interference effects in selective attention paradigms (e.g., Simon, Eriksen flanker). Some authors conclude that the alerting attentional network, activated by the alerting signal, reveals an inhibitory influence upon the executive attentional network, resulting in attenuated executive control. Alternatively, in the present study we argue that increased interference effects might be explained by alerting signals facilitating response activation processes (i.e., the activation of established S–R links). In a modified Eriksen-flanker paradigm, we contrasted these assumptions. We used word flanker stimuli for which S–R associations were established and word flanker stimuli without S–R associations. The presence of an alerting signal increased flanker compatibility only for flanker stimuli for which S–R associations existed while flanker compatibility effects were the same for all flanker types in conditions without alerting signals. Therefore, we conclude that alerting signals enhance stimulus triggered visuo-motor response activation processes.